Io was a peculiar and shy girl with green hair. Her hair unnatural hue of green was because she was engulfed by a Suiko Mushi, a traveling swamp. The Suiko Mushi saved Io when she was sacrificed by her village to become the bride of the swamp's spirit in order to prevent a flood. She then took up residence in the swamp and traveled with it until the Suiko's death. After the Mushi's death, Io began a new life in a nearby village. Her hair also reverted back to a normal black color.

Mushishi
They are neither plants nor animals. They differ from other forms of life such as the micro-organisms and the fungi. Instead they resemble the primeval body of life and are generally known as "Mushi". Their existence and appearance are unknown to many and only a limited number of humans are aware of them. Ginko is a "Mushi-shi" who travels around to investigate and find out more about the "Mushi". In the process, he also lends a helping hand to people who face problems with supernatural occurances which may be related to the "Mushi".