Izetta is the titular main character who met Princess Finé when they were children. Prior to the beginning of the series, she attempted to keep her witch heritage a secret by traveling around different countries with her grandmother, which made her shy and self-conscious. With the outbreak of the war she devotes herself to Finé's and Eylstadt's protection, thus breaking her taboo not to use her powers openly. Izetta's magical powers include animating and enhancing objects into tank-busting weapons. They are, however, hugely dependent on the presence of ley lines, which, depending on her current location, limits the frequency at which she can employ them. She is usually seen riding an anti-tank rifle in place of a broom, although she can use any rod-shaped object in a pinch, like medieval cavalry lances.

Izetta: The Last Witch
After Germania invaded a neighboring country in 1939, Europe spiraled into a devastating war. During the war, Germania set its sights on the weak alpine country of Elystadt. Boasting a far superior military and having achieved profuse success earlier in the war, it was expected that Germania would conquer Elystadt with ease. Matters are only made worse for the small country when Germanian soldiers capture their princess, Ortfiné "Finé" Fredericka von Eylstadt, as she is heading to a crucial meeting with Britannia. Yet, when a concurrent Germanian transport mission goes awry, Izetta, the last witch alive, escapes. When she recognizes Princess Finé from her childhood, Izetta rescues her from the Germanian soldiers by making use of her magical abilities. Now reunited with the princess, Izetta pledges to protect Elystadt from Germania, and with the last surviving witch on their arsenal, Elystadt hopes to turn the tides against the imperialist war giant.