A resident of Rush Valley, she lost her legs and right arm at a young age in a train wreck, but Dominic takes pity on her (in the form of social outrage) and gives her free automail legs and an arm. Thanks to these legs, she can run at great speed and jump great lengths. One leg also conceals a cannon, while the other has a long switchblade. She takes Ed, Al and Winry to see Dominic at Winry's wish. Paninya had made a living out of pickpocketing tourists in Rush Valley, but after a talk with Winry she realizes that being a criminal would defeat the purpose that Dominic intended for her when he gave her free legs. She is currently working legitimate odd jobs around Garfiel's shop. In the anime she also has an automail arm, which gets damaged in an arm wrestling contest. It also appears that Dominic adopted her after she lost her limbs in a train crash. No mention was made of what she did for a living, though in the chase with Edward, she was taking his pocketwatch to a pawn shop. However, this was most likely Winry's idea for Ed cheating in an automail contest. Since she is seen in Dominics shop it can be assumed that she might work for him. She was seen at the end of the anime, helping Winry perfect her skills. In the manga the only automail she possesses is her prosthetic legs. It is noted that one leg has a Carbine rifle built into it by Dominic and the other a blade. She pickpocketed from tourists to try to pay back Dominic, who lives out in the mountains of Rush Valley with his son, his wife, and herself, for her automail. Dominic always refuses to accept her stolen money. After reforming her ways, she becomes a roofer and Dominic begins to reluctantly accept her money.

Fullmetal Alchemist: Brotherhood
"In order for something to be obtained, something of equal value must be lost." Alchemy is bound by this Law of Equivalent Exchange—something the young brothers Edward and Alphonse Elric only realize after attempting human transmutation: the one forbidden act of alchemy. They pay a terrible price for their transgression—Edward loses his left leg, Alphonse his physical body. It is only by the desperate sacrifice of Edward's right arm that he is able to affix Alphonse's soul to a suit of armor. Devastated and alone, it is the hope that they would both eventually return to their original bodies that gives Edward the inspiration to obtain metal limbs called "automail" and become a state alchemist, the Fullmetal Alchemist. Three years of searching later, the brothers seek the Philosopher's Stone, a mythical relic that allows an alchemist to overcome the Law of Equivalent Exchange. Even with military allies Colonel Roy Mustang, Lieutenant Riza Hawkeye, and Lieutenant Colonel Maes Hughes on their side, the brothers find themselves caught up in a nationwide conspiracy that leads them not only to the true nature of the elusive Philosopher's Stone, but their country's murky history as well. In between finding a serial killer and racing against time, Edward and Alphonse must ask themselves if what they are doing will make them human again... or take away their humanity.